TB Meta-analysis: Tobacco, Alcohol, Diabetes, and BMI

Tobacco Smoking, Alcohol Drinking, Diabetes, Low Body Mass Index and the Risk of Self-Reported Symptoms of Active Tuberculosis: Individual Participant Data (IPD) Meta-Analyses of 72,684 Individuals in 14 High Tuberculosis Burden Countries

A new publication in Plos One from Patra et al examines the effects of varied risk factors for tuberculosis in high TB burden countries.

“The effects of multiple exposures on active tuberculosis (TB) are largely undetermined. We sought to establish a dose-response relationship for smoking, drinking, and body mass index (BMI) and to investigate the independent and joint effects of these and diabetes on the risk of self-reported symptoms of active TB disease.”

“Tobacco, alcohol, diabetes, and low BMI are significant individual risk factors but in combination are associated with triple or quadruple the risk of development of recent active TB. These risk factors might help to explain the wide variation in TB across countries.”

“The World Health Organization (WHO) estimated that 8.6 million people developed new tuberculosis (TB) infection and close to 1 million died of it in 2012. Over 95% of TB deaths occur in low- and middle-income countries (LMIC), and 22 high burden countries account for 82% of annual new cases globally.” [Read on...]

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